spiny mouse menstruation

All Rights Reserved. Population number. optical density for prolactin immunoreactivity was strongest. But DeMayo cautions that there is more to learn about how similar menstruation is in spiny mice and women, including the patterns of gene expression involved and how the hormones oestrogen and progesterone regulate the process in the mouse. There are few widely accepted theories on why menstruation developed as the preferred reproductive strategy of these select mammals, all of which reference the evolution of spontaneous decidualisation prior to … Researchers say the mice may make good models for studying human menstruation. OBJECTIVE: Here we describe the first observation of menstruation in a rodent, the spiny mouse (Acomys cahirinus). Now researchers at Monash University in Clayton, Australia, say that they have found a rodent that defies this conventional wisdom: the spiny mouse (Acomys cahirinus). Mice are a mainstay of biomedical research laboratories. Spiny Mice Are First Known Rodents to Have Menstrual Periods. There are few widely accepted theories on why menstruation developed as the preferred reproductive strategy of these select mammals, all of which reference the evolution of spontaneous decidualisation prior to … The spiny mouse undergoes spontaneous decidualisation, demonstrating for the first time menstruation in a rodent. Menstruation occurring without experimental … and a grant from the Victorian Government Infrastructure Support Fund to the Hudson Institute of Medical Research. Mice are a mainstay of biomedical research laboratories. The spiny mouse provides a readily accessible nonprimate model to study the mechanisms of menstrual shedding and repair, and may therefore be useful in furthering studies of human menstrual and pregnancy-associated disorders. The current animal model for endometriosis is the baboon, and primate research is expensive and time-consuming. The spiny mouse was found to undergo spontaneous decidualization and menstruation with a cycle of an average of 3 days duration every 6–10 days. The most recently discovered of these uncharacteristic traits: spontaneous decidual transformation of the uterus in virgin females, preceding menstruation. partner of AGORA, HINARI, OARE, INASP, CrossRef and COUNTER, Dirty room-mates make lab mice more useful, Fighting the menstruation taboo in the field, Preclinical research: Make mouse studies work, Deputy Director of Nanoscopy Center in SLST, ShanghaiTech, Vice Dean for Faculty Affairs in School of Life Science and Technology (SLST), ShanghaiTech University. STUDY DESIGN: Virgin female spiny mice (n = 14) aged 12–16 weeks were sampled through daily vaginal lavage for 2 complete reproductive cycles. We propose that DHEA, synthesised by the spiny mouse (but not other rodents), humans and other menstruating primates, is integral in spontaneous decidualisation and therefore menstruation. Conclusion: The spiny mouse is the first rodent species known to menstruate and provides an unprecedented natural non-primate model to study the mechanisms of menstrual Preprint at bioRxiv http://dx.doi.org/10.1101/056895 (2016). The IUCN Red List and other sources do not provide the Cairo spiny mouse total population size. Credit: Andy Mabbett/Wikipedia (Phys.org)—A team of researchers working at Monash University in Australia has found an example of a rodent that has a human-like menstrual cycle. The similarities expressed in the biology of this species with our own, strongly suggests correlations in behaviour between the spiny mouse and the human during the … This could provide information on how genes regulate different stages of the spiny mouse's menstrual cycle. Study co-author Hayley Dickinson., a reproductive physiologist at Monash University, says that the mouse discovery was hiding in plain sight. Scientists don’t know the source of the cells that repopulate the uterine lining after each menstrual cycle, he notes. The spiny mouse (Acomys species) has emerged as an exciting research organism due to its remarkable ability to undergo scarless regeneration of skin wounds and ear punches. There are no major threats to Cairo spiny mice at present. Part funding for this project was obtained from National Health & Medical Research Council of Australia to H.D. Financial Support: H.D. But the rodents are poor models for studying women’s reproductive health, because they don’t menstruate. No reuse allowed without permission. Prior to menses, endometrial transformation of the stroma corresponding to spontaneous decidualization was … Thank you for your interest in spreading the word about bioRxiv. The common spiny mouse (Acomys cahirinus) is the only known rodent to demonstrate a myriad of physiological processes unseen in their murid relatives. The spiny mouse could also help to shed light on healthy menstrual function, DeMayo says. First evidence of a menstruating rodent: the spiny mouse (, The Ritchie Centre, Hudson Institute of Medical Research, Obstetrics and Gynaecology, Monash University. Studies have investigated a variety of spiny mouse tissues to see how well they can regenerate, and the results prove that this species is a prime contender for regenerative medicine. With the exception of four bats and the elephant shrew, the common spiny mouse (Acomys cahirinus) is the only species outside the primate order to exhibit menses. NOTE: Your email address is requested solely to identify you as the sender of this article. menstruation. True menstruation has never been reported in rodents. Request PDF | Characterization of human-like menstruation in the spiny mouse: comparative studies with the human and induced mouse model | Study question: Is … The team have also sequenced and assembled the transcriptome of the spiny mouse, to characterise the genetics of this species. Article by Mental Floss Magazine. All Rights Reserved. scar) in response to tissue injury as most other mammals, including humans, do. Cairo spiny mouse. Main results and the role of chance: Menstruation occurs in the spiny mouse over a 72-h period, with heaviest menstrual breakdown occurring 24 h after initial observation of red blood cells in the vaginal cytology. Our award-winning show features highlights from the week's edition of Nature, interviews with the people behind the science, and in-depth commentary and analysis from journalists around the world. One species of spiny mouse was recently discovered to have a menstrual cycle which would make them important as a model organism to study menstruation and reproductive disorders, as Mus musculus, the common laboratory mouse, does not menstruate. Results Mean cycle length was 8.7 ± 0.4 days with red blood cells observed in the lavages over 3.0 ± 0.2 days. Menstruating species account for only 1.5% of mammals, and less than 0.09% of these are non-primates. Therefore, a mouse model of menstruation may provide a strong theoretical foundation for studies on the treatment of reproductive and gynaecological diseases in humans. Menstruation occurs as a consequence of progesterone priming of the endometrial stroma and a spontaneous decidual reaction. OBJECTIVE: Here we describe the first observation of menstruation in a rodent, the spiny mouse (Acomys cahirinus). Abstract. Mouse model of menstruation. AGORA, HINARI, OARE, INASP, CrossRef and COUNTER. But he is intrigued. The spiny mouse could one day aid studies of women's reproductive problems. The spiny mouse undergoes spontaneous decidualization, demonstrating for the first time menstruation in a rodent. Paper presentation information: Society for Reproductive Investigation 63rd Annual Scientific Meeting, Montreal, Quebec, Canada, March 16–19, 2016; Perinatal Society of Australia and New Zealand, Townsville, Queensland, Australia May 22–25, 2016. Menstruation occurs in the spiny mouse over a 72-h period, with heaviest menstrual breakdown occurring 24 h after initial observation of red blood cells in the vaginal cytology. “There’s some really simple studies that they could do to see if these animals would develop endometriosis spontaneously,” he says. The researchers found that the animals averaged a 9-day menstrual cycle and spent 3 days — or 20–40% of their cycle — bleeding. Inset square shows magnified spiral arteries (A, B, C). True menstruation has never been reported in rodents. The majority of menstruating species are higher order Non-normal data are displayed as the median values of replicates (with interquartile range) and significant differences calculated using Kruskal-Wallis test. This animal is common and widespread throughout its known range. Menstruation is the shedding of the uterine lining (endometrium).It occurs on a regular basis in uninseminated sexually reproductive-age females of certain mammal species.. © 2019 Macmillan Publishers Limited, part of Springer Nature. For a long time, previous studies had not attempted to develop a mouse model of menstruation, because mice do not menstruate under normal conditions. The belief that rodents don’t menstruate has led scientists to consider them poor … Warren Nothnick, a researcher at the University of Kansas in Kansas City who studies the uterine-lining disorder endometriosis, says that it will take a lot of work to prove that the spiny mouse is a good model for human menstruation. The scientists also dissected uteri taken from four spiny mice, each at a different stage of the menstrual cycle. You will be re-directed back to this page where you will see comments updating in real-time and have the ability to recommend comments to other users. The endometrium was thickest during the luteal phase, when plasma progesterone peaked at ~102.1 ng/mL and the optical density for prolactin immunoreactivity was strongest. While reproduction in every other rodent is dictated by the environment and, importantly, the lining of the womb is not shed, the spiny mouse … With the exception of four bats and the elephant shrew, the common spiny mouse (Acomys cahirinus) is the only species outside the primate order to exhibit menses. AF: Late secretory phase. For a mammal, it displays surprising powers of regeneration because it does not fibrose (i.e. This question is for testing whether or not you are a human visitor and to prevent automated spam submissions. Cyclic endometrial shedding and blood in the vaginal canal concluding with each infertile cycle was confirmed in all virgin females. ... Learning about mouse menstruation could … The spiny mouse averages a 9-day menstrual cycle. Thus, many aspects of this phenomenon remain poorly understood limiting the development of efficacious treatment for women. Study Design Virgin female spiny mice (n=14) aged 12-16 weeks were sampled through daily vaginal lavage for 2 complete reproductive cycles in our in-house colony at Monash Medical Centre, Clayton, Australia. We have confirmed the spiny mouse has a menstrual cycle ranging from 6 to 10 days (mean 8.7 ± 0.4 days) with a menstrual period lasting on average 3 days. Bellofiore, N. et al. This thesis details the discovery of the only naturally menstruating rodent, the spiny mouse. A finding that the animals do develop the disease naturally would be a major breakthrough, Nothnick adds. Aspects of this phenomenon remain poorly understood limiting the development of efficacious treatment women... Only if their ovaries are removed and they are given abnormally large of... For the first rodent known to have a menstrual cycle and spent 3 duration. Repopulate the uterine lining after each menstrual cycle register as a consequence progesterone. Results mean cycle length was 8.7 ± 0.4 days with red blood cells observed in the endometrium of spiny. In the lavages over 3.0 ± 0.2 days for your interest in spreading the word about.. Experimental … There are no major threats to Cairo spiny mice, each at a different stage the! Of the spiny mouse ( Acomys cahirinus ) recently described model organism for studies., demonstrating for the best commenting experience, please login or register as a user and agree to Community. Infrastructure Support Fund to the nearby Hudson Institute of Medical Research 6–10 days thus, many aspects this. 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